Blar i Brage NIH på forfatter "Morales-Alamo, David"
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Angiotensin-converting enzyme 2 (SARS-CoV-2 receptor) expression in human skeletal muscle
Perez-Valera, Mario; Martinez-Canton, Miriam; Gallego-Selles, Angel; Gelabert-Rebato, Miriam; Morales-Alamo, David; Santana, Alfredo; Martin-Rodriguez, Saul; Larsen, Steen; Losa-Reyna, Jose; Perez-Suarez, Ismael; Dorado, Cecilia; Curtelin, David; Gonzalez-Henriquez, Juan Jose; Boushel, Robert; Hallén, Jostein; de Pablos-Velasco, Pedro; Freixinet-Gilart, Jorge; Calbet, Jose Antonio Lopez; Galván-Alvarez, Victor; Ponce-Gonzalez, Jesus Gustavo (Peer reviewed; Journal article, 2021)The study aimed to determine the levels of skeletal muscle angiotensin-converting enzyme 2 (ACE2, the SARS-CoV-2 receptor) protein expression in men and women and assess whether ACE2 expression in skeletal muscle is ... -
Antioxidant enzymes and Nrf2/Keap1 in human skeletal muscle: Influence of age, sex, adiposity and aerobic fitness
Galvan-Alvarez, Victor; Gallego-Selles, Angel; Martinez-Canton, Miriam; García-Gonzalez, Eduardo; Gelabert-Rebato, Miriam; Ponce-Gonzalez, Jesus Gustavo; Larsen, Steen; Morales-Alamo, David; Losa-Reyna, Jose; Perez-Suarez, Ismael; Dorado, Cecilia; Perez-Valera, Mario; Holmberg, Hans-Christer; Boushel, Robert; Velasco, Pedro de Pablos; Helge, Jørn Wulff; Martin-Rincon, Marcos; Calbet, José Antonio López (Peer reviewed; Journal article, 2023)Ageing, a sedentary lifestyle, and obesity are associated with increased oxidative stress, while regular exercise is associated with an increased antioxidant capacity in trained skeletal muscles. Whether a higher aerobic ... -
Exercise mitigates the loss of muscle mass by attenuating the activation of autophagy during severe energy deficit
Martin-Rincon, Marcos; Pérez-López, Antonio; Morales-Alamo, David; Perez-Suarez, Ismael; de Pablos-Velasco, Pedro; Perez-Valera, Mario; Perez-Regalado, Sergio; Martinez-Canton, Miriam; Gelabert-Rebato, Miriam; Juan-Habib, Julian William; Holmberg, Hans-Christer; Calbet, Jose Antonio Lopez (Peer reviewed; Journal article, 2019)The loss of skeletal muscle mass with energy deficit is thought to be due to protein breakdown by the autophagy-lysosome and the ubiquitin-proteasome systems. We studied the main signaling pathways through which exercise ... -
Fast regulation of the NF-κB signalling pathway in human skeletal muscle revealed by high-intensity exercise and ischaemia at exhaustion: Role of oxygenation and metabolite accumulation
Gallego-Selles, Angel; Galvan-Alvarez, Victor; Martinez-Canton, Miriam; Garcia-Gonzalez, Eduardo; Morales-Alamo, David; Santana, Alfredo; Gonzalez-Henriquez, Juan Jose; Dorado, Cecilia; Calbet, Jose Antonio Lopez; Martin-Rincon, Marcos (Peer reviewed; Journal article, 2022)The NF-κB signalling pathway plays a critical role in inflammation, immunity, cell proliferation, apoptosis, and muscle metabolism. NF-κB is activated by extracellular signals and intracellular changes in Ca2+, Pi, H+, ... -
Functional reserve and sex differences during exercise to exhaustion revealed by post-exercise ischaemia and repeated supramaximal exercise
Martin-Rincon, Marcos; Gelabert-Rebato, Miriam; Perez-Valera, Mario; Galvan-Alvarez, Victor; Morales-Alamo, David; Dorado, Cecilia; Boushel, Robert; Hallén, Jostein; Calbet, José Antonio López (Peer reviewed; Journal article, 2021)The purpose of this study was to ascertain what mechanisms explain sex differences at task failure and to determine whether males and females have a functional reserve at exhaustion. Exercise performance, cardiorespiratory ... -
Impact of data averaging strategies on V̇O2max assessment: Mathematical modeling and reliability
Martin-Rincon, Marcos; Gonzalez-Henriquez, Juan Jose; Losa-Reyna, Jose; Perez-Suarez, Ismael; Ponce-Gonzalez, Jesus Gustavo; de La Calle-Herrero, Jaime; Perez-Valera, Mario; Perez-Lopez, Alberto; Curtelin, David; Cherouveim, Evgenia D; Morales-Alamo, David; Calbet, Jose Antonio Lopez (Peer reviewed; Journal article, 2019)Background: No consensus exists on how to average data to optimize VO2max assessment. Although the VO2max value is reduced with larger averaging blocks, no mathematical procedure is available to account for the effect of ... -
An integrative approach to the regulation of mitochondrial respiration during exercise: Focus on high-intensity exercise
Calbet, Jose Antonio Lopez; Martín-Rodríguez, Saúl; Martin-Rincon, Marcos; Morales-Alamo, David (Peer reviewed; Journal article, 2020)During exercise, muscle ATP demand increases with intensity, and at the highest power output, ATP consumption may increase more than 100-fold above the resting level. The rate of mitochondrial ATP production during exercise ... -
Mitochondrial oxygen affinity increases after sprint interval training and is related to the improvement in peak oxygen uptake
Larsen, Filip J.; Schiffer, Tomas A.; Zinner, Christoph; Willis, Sarah J.; Morales-Alamo, David; Calbet, Jose Antonio Lopez; Boushel, Robert; Holmberg, Hans-Christer (Peer reviewed; Journal article, 2020)Aims: The body responds to exercise training by profound adaptations throughout the cardiorespiratory and muscular systems, which may result in improvements in maximal oxygen consumption (VO2peak) and mitochondrial capacity. ... -
Regulation of Nrf2/Keap1 signalling in human skeletal muscle during exercise to exhaustion in normoxia, severe acute hypoxia and post-exercise ischaemia: Influence of metabolite accumulation and oxygenation
Gallego-Selles, Angel; Martin-Rincon, Marcos; Martinez-Canton, Miriam; Perez-Valera, Mario; Martín-Rodríguez, Saúl; Gelabert-Rebato, Miriam; Santana, Alfredo; Morales-Alamo, David; Dorado, Cecilia; Calbet, Jose Antonio Lopez (Peer reviewed; Journal article, 2020)The Nrf2 transcription factor is induced by reactive oxygen and nitrogen species and is necessary for the adaptive response to exercise in mice. It remains unknown whether Nrf2 signalling is activated by exercise in human ... -
Supplementation with a mango leaf extract (Zynamite®) in combination with quercetin attenuates muscle damage and pain and accelerates recovery after strenuous damaging exercise
Martin-Rincon, Marcos; Gelabert-Rebato, Miriam; Galvan-Alvarez, Victor; Gallego-Selles, Angel; Martinez-Canton, Miriam; Lopez-Rios, Laura; Wiebe, Julia C.; Martin-Rodriguez, Saul; Arteaga-Ortiz, Rafael; Dorado, Cecilia; Perez-Regalado, Sergio; Santana, Alfredo; Morales-Alamo, David; Calbet, Jose Antonio Lopez (Peer reviewed; Journal article, 2020)Prolonged or unusual exercise may cause exercise-induced muscle damage (EIMD). To test whether Zynamite®, a mango leaf extract rich in the natural polyphenol mangiferin, administered in combination with quercetin facilitates ... -
Treatment of hypertension with angiotensin-converting enzyme inhibitors or angiotensin receptor blockers and resting metabolic rate: A cross-sectional study
Pedrianes-Martin, Pablo B.; Martin-Rincon, Marcos; Morales-Alamo, David; Perez-Suarez, Ismael; Perez-Valera, Mario; Galvan-Alvarez, Victor; Curtelin, David; de Pablos-Velasco, Pedro; Calbet, Jose Antonio Lopez (Peer reviewed; Journal article, 2021)Hypertension in obese and overweight patients is associated with an elevated resting metabolic rate (RMR). The aim of this study was to determine whether RMR is reduced in hypertensive patients treated with angiotensin-converting ...